Mitchell had 30 points for the Cavaliers, who recorded their seventh successive victory, their best start to a season since Bill Fitch coached them to a franchise-record 8-0 start in 1976-77.
Sam Merrill contributed 17 points off the bench, including five 3-pointers, Jarrett Allen had 15 points and 12 rebounds, Evan Mobley had 14 points and seven boards and Darius Garland finished with 11 points and 10 assists.
Damian Lillard notched 41 points – including 10 3-pointers – and nine assists, Giannis Antetokounmpo piled on 34 points, 16 rebounds and nine assists and Taurean Prince scored 16 for the Bucks.
Elsewhere, Jayson Tatum pumped in 29 points and Payton Pritchard hit six 3-pointers on the way to 22 points off the bench as Boston Celtics defeated host Charlotte Hornets 113-103.
Jay Huff scored a career-high 20 points in 14 minutes to highlight a balanced attack by the Grizzlies in defeating 76ers 124-107 in Philadelphia.
RJ Barrett had 31 points, including five in overtime, and nine rebounds as Toronto Raptors defeated visiting Sacramento Kings 131-128.
Buddy Hield scored 27 points off the bench and Jonathan Kuminga added six of his 23 points in overtime as Golden State Warriors scraped past Rockets 127-121 in Houston.
Bam Adebayo had 32 points and grabbed 14 rebounds to lead Miami Heat to a 118-98 win over Washington Wizards in Mexico City.
Devin Booker recorded 28 points, nine rebounds and nine assists to help Phoenix Suns beat visiting Portland Trail Blazers 103-97.
Keldon Johnson poured in a season-high 25 points off the bench and Jeremy Sochan and Chris Paul amassed double-doubles as San Antonio Spurs defeated visiting Minnesota Timberwolves 113-103.
Shai Gilgeous-Alexander had 25 points and nine assists as visiting Oklahoma City Thunder remained unbeaten with a 105-92 victory over Los Angeles Clippers.
Nikola Jokic scored 18 of his 27 points in the third quarter, and host Denver Nuggets defeated Utah Jazz 129-103 for its first home win of the season.