Italians and Swiss have long had close ties, sharing a border and Italian is one of the official languages of Switzerland, but that will all be forgotten in Berlin.
Italy and Switzerland have met 61 times, the most common opponent for each country and while the Swiss have beaten the Italians only eight times, most recently in 1993, they have impressed more in Germany.
Switzerland came close to topping Group A before conceding an added-time equaliser in the final game against hosts Germany, and it was a performance which showed they have no fear of anyone at this tournament.
Italy needed a late goal to snatch a 1-1 draw with Croatia to progress, and the defending champions have failed to impress, unlike Euro 2020 when they eased through the group stage and beat the Swiss comfortably.
After seeing off Turkey 3-0 in their opening game three years ago, Italy beat Switzerland by the same score.
Bologna were a team who took Serie A by storm last season, finishing fifth in the standings to secure Champions League football and there could be as many as three Bologna players on the pitch in Berlin, all on the Swiss side.
Unfortunately for Italy, Luciano Spalletti will not have Riccardo Calafiori available, with the Bologna defender suspended. Calafiori made the opposite move to many Swiss players when joining Basel before returning to Italy.
Midfielder Michel Aebischer scored in Switzerland’s 3-1 opening win over Hungary, forward Dan Ndoye put them in front against Germany Remo Freuler completes the Swiss Bologna trio.
“I’m sorry for Riccardo, really. I would have liked to have faced him at the Olympiastadion,” Freuler said.
“On Saturday, however, the challenge will be Switzerland against Italy. Not Bologna against Italy.”
Freuler was on loan at Bologna from Nottingham Forest last season, but before that he spent six years at Atalanta, and this will be no ordinary game for the 32-year-old.
“Of course, it’s not a match like any other for me. In Italy I built my career, also finding an ideal country to spend my life with my family,” he said.
“On Saturday, however, there won’t be all this love. It’s a round of 16 and there will be no room for feelings.”
Freuler knows the next part of the tournament is where the Swiss will really be judged.
“Doing well in the first part of the tournament is important. The matches that make the difference, those capable of changing the dimension of a national team, however, are others,” Freuler said.
“But I’m not afraid. And Switzerland are not afraid of Italy.”